Clinical Evaluation of Youth with Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS): Recommendations from the 2013 PANS Consensus Conference, Journal of Child and Adolescent Psychopharmacology, Feb 1, 2015, Kiki Chang, Jennifer Frankovich, Michael Cooperstock, et al

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Journal of Child and Adolescent Psychopharmacology, Volume 27, Issue 7, Mary Ann Liebert, Inc., September 2017, Swedo, MD, Frankovich, MD, MS, Murphy, MD, MS

List of Articles To Refer

Introduction - Overview of Treatment of Pediatric Acute-Onset Neuropsychiatric Syndrome Swedo, MD, Frankovich, MD, MS, Murphy, MD, MS
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Clinical Management of PANS

Part I - Psychiatric and Behavioral Interventions, Thienemann, MD, et al. Presents consensus guidelines for treating the psychiatric and behavioral symptoms of children with PANS/PANDAS. Symptom improvement is aimed at decreasing suffering, improving functioning, and making it easier for the children to adhere to therapeutic interventions.
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Part II - Use of Immunomodulatory Therapies, Frankovich, MD, et al. Provide recommendations to help guide the use of therapies targeting the neuroinflammation and post-infectious autoimmunity that are common in PANS-PANDAS.
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Part III - Treatment and Prevention of Infections, Cooperstock, MD, MPH, et al. Present a consensus guideline for managing the infection components of these neuropsychiatric conditions.
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Platt MP, Bolding KA, Wayne CR, Chaudhry S, Cutforth T, Franks KM, Agalliu D. Th17 lymphocytes drive vascular and neuronal deficits in a mouse model of postinfectious autoimmune encephalitis. Proc Natl Acad Sci U S A. 2020 Mar 24;117(12):6708-6716. doi: 10.1073/pnas.1911097117. Epub 2020 Mar 11. PMID: 32161123; PMCID: PMC7104239.

This article demonstrates that Th17 lymphocytes are critical for entry of autoantibodies into the CNS, persistent microglia activation, and neurophysiological deficits in odor processing, in a mouse model of postinfectious autoimmune encephalitis triggered by multiple infections with group A Streptococcus. Our findings emphasize the critical role that Th17 lymphocytes play in disease pathogenesis to impair CNS function in AE syndromes.

Dritan Agalliu, PhD is an Assistant Professor in the Departments of Neurology and Pathology and Cell Biology at Columbia University Irving Medical Center. Dr. Agalliu is a neuroscientist with 22 years of research experience in developmental, cellular and molecular neuroscience and specializing in the interaction of brain and blood vessels in the healthy and diseased Central Nervous System (CNS). Read more about Dr. Agalliu and other Professional Advisory Board Members.

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Antibodies From Children With PANDAS Bind Specifically to Striatal Cholinergic Interneurons and Alter Their Activity Jian Xu, Rong-Jian Liu, Shaylyn Fahey, Luciana Frick, James Leckman, Flora Vaccarino, Ronald S. Duman, Kyle Williams, Susan Swedo, and Christopher Pittenger. Am Jrnl of Psychiatry 16 Jun 2020

• https://doi.org/10.1176/appi.ajp.2020.19070698

Also, see

• ASPIRE’s interview with Christopher Pittenger, MD, PhD, FAPA, FANA 

• Dr. Bob Naviaux’s suramin study at UCSD, published in May 2017: R. Naviaux, et al. Low-dose suramin in autism spectrum disorder: a small, phase I/II, randomized clinical trial Annals of Clinical and Translational Neurology 2017
• UCSD whiteboard animation on suramin study/cell danger response

Discover the Fundamentals of Functional Medicine!

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Super Sam! And the battle against PANS/PANDAS by Lindsey Wells, ND

“A terrific book for families who know someone with PANS/PADNAS, who are dealing with it themselves, or who just want to read a good story about Super Sam, his family’s journey to Dogotr Ed and the effects of PANS/PANDAS” – Nancy O’Hara, MD, MPH, FAAP

You Finished Treatment, Now What?  A Field Guide For Cancer Survivors by Amy Rothenberg, ND

You Finished Treatment, Now What? is a road map for lifestyle and natural medicine approaches to address health challenges that persist after cancer care, and to reduce the risk of recurrence. Written for cancer survivors/thrivers, those who care for them, as well as health-care providers, You Finished Treatment highlights the evidence for an integrative approach to healing. Dr. Amy Rothenberg, a licensed naturopathic doctor and cancer survivor/thriver herself, makes sense of an overwhelming topic, in a user- friendly accessible way, providing actionable information and inspiration. 

The First Rule of Climate Club By Carrie Firestone

In this companion to Dress Coded, an eighth-grader starts a podcast on climate activism and rallies her friends to create lasting change in their local community and beyond. The First Rule of Climate Club, a mid-grade novel, focuses on an eighth grader’s efforts to help diagnose her friend’s “mystery illness,” which eventually is identified as PANS from Lyme disease.